The latest on herpes vaccines: Are we getting closer?

The latest on herpes vaccines: Are we getting closer?

Herpes is one of the most common viral infections in the world, and millions live with either HSV-1 or HSV-2. Although outbreaks are usually harmless, they can be painful, embarrassing, and emotionally distressing. That’s why many rightly ask, “When will there be a herpes vaccine?”

In this blog post, we take a closer look at the status of herpes vaccines in 2025 – and whether we are approaching a breakthrough.

Why don't we still have a herpes vaccine?

The herpes simplex virus is complex. After the initial infection, the virus goes into a latent state in the body's nerve cells and can reactivate later. This makes it difficult to develop a vaccine that not only prevents infection but also keeps the virus inactive for years.

Previous vaccine trials have had limited effectiveness – especially against HSV-2, which causes genital herpes. Some vaccines have only protected against HSV-1, others have had very short-term effects. But research is far from stagnant.

What is being researched right now?

1. mRNA vaccines (like the COVID-19 vaccines)
Several biotech companies are working on mRNA technology against herpes. This approach may trigger a more targeted immune response – both against infection and reactivation.

2. Therapeutic vaccines
Instead of preventing infection, these vaccines attempt to help the body control existing viruses and reduce outbreaks.

3. Combination of antibodies and immune activation
Some vaccines combine injected antibodies with T-cell activation, and this looks promising in animal studies.

Several of these candidates are in clinical phase 2 – this means that they are being tested on humans but are not yet approved for use.

When can we expect a vaccine?

The most optimistic estimates say 2027–2028 at the earliest, if one of the current candidates proves effective and safe. But the reality is that research and approval take time, and many vaccines never quite reach their goal.

What can be done until then?

Until a vaccine is available, it's all about symptom relief and prevention. This includes:

• Getting to know your triggers (stress, sun, illness)
• Responding quickly at the first sign of an outbreak
• Using a good herpes cream or gel to soothe and protect the skin

QUR herpes gel is an effective choice for many who want to minimize the duration and discomfort of herpes outbreaks. The best effect is achieved by starting treatment at the very first symptoms of an outbreak. Therefore, it is a good idea to have a small tube in the drawer so that you are ready when the next time you have your next outbreak, hopefully in a long time.

Conclusion

Research into herpes vaccines is in full swing – and advances in mRNA and immunotherapy offer hope. But until a vaccine becomes a reality, the most important thing is to take care of yourself, respond early, and use effective products like QUR herpes gel to minimize your outbreaks and improve your quality of life.